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Symbol
Name
ID

Rac1
Rac family small GTPase 1
MGI:97845

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Hypoplasia of the brainstem

Dilated fourth ventricle

Lateral ventricle dilatation

Polymicrogyria

Hypoplasia of the corpus callosum

Cerebellar vermis hypoplasia

Dysgenesis of the cerebellar vermis

Cerebellar hypoplasia

Cerebellar dysplasia

Absent speech

Autistic behavior

Hyperactivity

Motor stereotypy

Intellectual disability

Sleep abnormality

Seizure

Disease(s) Associated with RAC1

autosomal dominant intellectual developmental disorder 48

Mouse Phenotypes		abnormal neural tube closure	abnormal brain commissure morphology	abnormal corpus callosum morphology	decreased hippocampal commissure size	decreased anterior commissure size	abnormal dentate gyrus morphology	abnormal hippocampus pyramidal cell layer	small hippocampus	abnormal telencephalon morphology	abnormal barrel cortex morphology
Availability	Mouse Genotype	abnormal neural tube closure	abnormal brain commissure morphology	abnormal corpus callosum morphology	decreased hippocampal commissure size	decreased anterior commissure size	abnormal dentate gyrus morphology	abnormal hippocampus pyramidal cell layer	small hippocampus	abnormal telencephalon morphology	abnormal barrel cortex morphology
	Rac1^tm1Tyb/Rac1^tm2Tyb Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)
	Emx1^tm1(cre)Ito/Emx1⁺ Rac1^tm1Atai/Rac1^tm1Jms (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23